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NSAIDs like Ibuprofen and Diclofenac can affect both kidneys and liver, especially if used in high doses or for a long time. They reduce kidney blood flow, which may cause acute kidney injury, fluid retention, and increased blood pressure, particularly in elderly or dehydrated patients. In the liver, they may raise liver enzymes and rarely cause hepatitis. Kidney problems are more common than liver damage, so NSAIDs should be used in the lowest effective dose for the shortest duration. #medicals
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