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When a double-stranded DNA molecule is exposed to high temperature, the two strands separate, and the molecule loses its helical form. We say the DNA has been denatured. (Denaturation also occurs when DNA is exposed to acid or alkaline solutions.) a. Regions of the DNA that contain many A-T base pairs are the first to become denatured as the temperature of a DNA solution is raised. Thinking about the chemical structure of the DNA molecule, why do you think the A-T-rich regions denature first? b.
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