Crushing delayed-release meds can alter the mechanism designed to protect the drug from gastric acids or prevent gastric mucosal irritation. Crushing sublingual or buccal tabs can alter effectiveness.

delay onset of action Designed to release drug over an extended period of time. Such products include: multiple-layer tablets releasing drug as each layer is dissolved. mixed release pellets that dissolve at …

All medications listed in this policy must be crushed unless specifically labeled or noted by the Pharmacy Department as DO NOT CRUSH (e.g., sustained release, special formulations).

The following table contains available drugs that have characteristics that may make it inappropriate to crush or alter the dosage form to help facilitate drug delivery.

Multi-source surveillance for work-related crushing injuries.

When patients cannot take pills: antiretroviral drug formulations for managing adult HIV infection. Top Antivir Med 2011;19:126-31. Kim CH, Muzevich KM, Fulco PP. Orogastric administration of crushed …

For victims of an acute crush injury, < 2 hours of entrapment, consider crush injury Key to treatment is comprehensive therapy, including thorough and rapid reduction in tension to the affected site •