Jun 27, 2024 · Valacyclovir treatment may be associated with acute kidney injury, and clinicians should be aware of this and elicit a history of recent exposure to valacyclovir and other nephrotoxins when …

Aug 26, 2025 · Taking valacyclovir with other medications that are hard on the kidneys — such as nonsteroidal anti-inflammatory drugs (NSAIDS) — and taking higher dosages also increase the risk.

Valacyclovir is a prodrug and is rapidly converted to acyclovir in the body, and it has higher bioavailability when taken orally compared with acyclovir. Acyclovir-induced acute kidney injury is …

Nov 22, 2025 · While rare, valacyclovir can cause acute kidney injury, especially in older adults, those with pre-existing kidney disease, or dehydration. Learn about the risks and how to prevent them.

Taken long term, particularly in people with existing kidney issues and/or inadequate hydration, valacyclovir can lead to renal toxicity and kidney failure. It can also lead to inflammation of the liver in …

Valacyclovir-induced nephrotoxicity and/or neurotoxicity are not common problems encountered in clinical practice and often they occur with intravenous administration, inappropriate dosing, when …

Learn how to safely adjust Valacyclovir dosage based on kidney function with this easy-to-follow renal dosing guide. Stay safe and informed.

Valacyclovir related acute kidney injury (AKI) is described as a rare side effect. The mechanism of nephrotoxicity includes crystal deposition in the renal tubules resulting in intratubular obstruction and …

This paper will present a case of valacyclovir-associated acute kidney injury and discuss its pathophysiology, diagnosis, management and prevention.

Nov 5, 2025 · Case studies and adverse event reports show that valacyclovir can cause acute kidney injury, particularly in patients with pre-existing kidney disease, dehydration, or when high doses are …