A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...

Even before a tumor in the pancreas becomes discernible, an activated cancer gene actively remodels its future environment ...

New research shows that physical pressure from brain tumors or injuries triggers a "self-destruction" program in neurons, leading to irreversible brain damage.

As is often the case with cancer treatments, many patients are able to benefit from therapy for a time. Tumor activity decreases, scans show improvement, and patient lifespans are prolonged for some ...

A new study published by Mayo Clinic researchers suggests that ovarian cancer cells quickly activate a survival response ...

Liver cancer is one of the three deadliest cancers worldwide, and metabolic dysfunction-related cases have become ...

Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs, MDSCs, and Tregs-orchestrate a tumor-permissive microenvironment.

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Combined epigenetic and immune checkpoint therapy altered the tumour microenvironment in platinum-resistant ovarian cancer.