Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

The processing of messenger RNA during splicing requires the activity of a complex of RNAs and proteins termed the spliceosome. Structural data shed light on previously mysterious aspects of splicing ...

The eukaryotic spliceosome is a multi-megadalton ribonucleoprotein (RNP) complex found in eukaryotic nuclei that catalyzes the removal of introns (non-coding regions) from pre-mRNA and splices exons ...

There are bells and whistles on the human spliceosome that allow it to process specific introns more efficiently. One of the advantages of a system like this may be that it allows more complex types ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic ...

Individuals with Usher syndrome (USH) are born deaf and begin to suffer retinal degeneration from puberty, eventually losing their eyesight as the disease progresses. USH is the most common cause of ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...