Study identifies impaired ER-to-golgi ceramide transport as a key regulatory node underlying senescence-associated sphingolipid remodeling.

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.

As population aging accelerates worldwide, aging-related diseases have become a major challenge in both life science and ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as ...

A new research paper was published in Volume 18 of Aging-US on February 10, 2026, titled “Aging-associated mitochondrial circular RNAs.” Led by first author Hyejin Mun from the University of Oklahoma ...

Mitochondria, once primarily recognized for their role in energy production, have emerged as crucial components in a wide ...

Mitochondria are central regulators of cellular metabolism, redox balance, and cell survival in the nervous system. In recent years, growing evidence has ...

NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...

Cellular senescence is marked by irreversible cell cycle arrest, lysosomal changes, regulatory protein expression, and SASP activation, impacting tissue health and repair. Cellular senescence is a ...

Ceramide buildup due to faulty transport triggers stress responses that lock cells into senescence, revealing a potential ...