This is a summary of: Liu. H. et al. Viral RNA blocks circularization to evade host codon usage control. Nature https://doi.org/10.1038/s41586-025-09809-y (2025).

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER). Inspired by natural mechanisms found in ...

The BioPORTER ® protein delivery reagent from AMSBIO has been proven to efficiently transport functionally active proteins directly into living cells, eliminating the traditional DNA transfection, ...

A research team has developed DeepCodon, a deep learning–based codon optimization tool that significantly improves heterologous protein expression in Escherichia coli while preserving functionally ...

Scientists at the University of California, Santa Cruz, have trapped the ribosome, a protein-building molecular machine essential to all life, in a key transitional state that has long eluded ...

Sec61 is a critical component of the protein translocation machinery that mediates the entry of most secreted and transmembrane proteins into the endoplasmic reticulum. Sec61 has been proposed as a ...

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control ...

The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging ...

In eukaryotic cells—found in animals, plants, and fungi—protein synthesis involves more than the simple assembly of amino acids in ribosomes. Nearly one-third of all human proteins must be transported ...