Indeed there is a lot to do, and Alzforum will do its part with a series of news summaries over the next two weeks. First up: progranulin as a therapeutic target. In people with deleterious variants ...

Mutations that douse expression of the progranulin protein underlie nearly a third of familial frontotemporal dementia cases. Could scientists simply replace what is missing? Multiple progranulin ...

Transcutaneous punch biopsies of 6 or 8 mm diameter were made on the backs of 3- to 4-month-old female Swiss NIH mice [22]. Animal use throughout complies with Animal Use Committee guidelines of the ...

-Latozinemab is the most advanced progranulin-elevating candidate in development for FTD-GRN and has now become the first investigational medicine to receive a Breakthrough Therapy Designation for the ...

Neurodegenerative diseases are a group of debilitating disorders characterized by progressive degeneration of nerve cells and a range of associated clinical symptoms, including motor, cognitive, and ...