A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...

Not only will the advance make it easier to produce genetically modified mice, but it may also enable genetic modification of animals that can't be modified by today's means. The technique might ...

DNA replication is a major determinant in the targeting reaction in many cell types. Consequences of single-stranded oligodeoxyribonucleotides (ssODN)-mediated gene targeting on cell viability are ...

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development, showing how the 3D structure of chromatin — DNA and proteins — plays a critical role.