MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...
7don MSN
Ovarian cancer cells surprise scientists—the body's own defense may be the key to longer survival
A new study sheds light on why some patients with the most aggressive form of ovarian cancer respond better to treatment than others. Tumors positive for a molecule called MHC class II are linked to ...
Once cells’ quality control mechanism is activated, IRGQ (red) accumulates in special cell organelles, the lsysosomes (green). This is also where the degradation of the non-functional MHC-I molecules ...
Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...
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