BIN1, a late-onset Alzheimer’s disease (LOAD) genetic risk factor, is involved in many cellular phenomena, including vesicular trafficking and tau production. Now, in the August 26 Cell Reports, ...

A researcher has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their study sheds light on the crucial role of ...

Labeling of intraregional synapses using LCD-eGRASP in the basolateral amygdala (BLA). Engram cells (Red), Non-engram cells (White), synapses from activated inhibitory interneurons (yellow), and ...

Scientists have developed a powerful new method for selectively and reversibly breaking connections between brain cells—a leap forward that could transform how we study brain processes and, one day, ...

From Santiago Ramón y Cajal’s hand came branches and whorls, spines and webs. Now-famous drawings by the neuroanatomist in the late 19th and early 20th centuries showed, for the first time, the ...

Memory, a fundamental tool for our survival, is closely linked with how we encode, recall, and respond to external stimuli. Over the past decade, extensive research has focused on memory-encoding ...

Gotcha! Scientists spot where, and possibly how, p-tau217 first appears in the brain. In a postmortem study of individuals spanning the Alzheimer’s disease spectrum, researchers led by Michiko Sekiya ...

What am I looking at? This is a video showing a section of the cerebral cortex from a mouse. The video was taken by moving the focal plane of a microscope from the bottom of a thick section of brain ...

To expand the understanding of memory, a research team has developed a technology called LCD-eGRASP (local circuit dual-eGRASP) that can label synapses of neural circuits within a specific brain ...