Since its first description by Ehrlich in the late 1890s and subsequent characterization by Bordet, the complement cascade has been thought to have important and varied roles in the immune response.

The complement system is an important part of the humoral immune defence in mammals that is formed by about 35 soluble and cell-surface proteins. Together these proteins enable the host to recognize ...

Humoral immunity produces antigen-specific antibodies and is primarily driven by B cells. Cell-mediated immunity on the other hand does not depend on antibodies for its adaptive immune functions and ...