In fish, multiple HBD of CTR and stable É‘-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent ...
Calcitonin-salmon (rDNA origin) 200 IU/spray; nasal spray. Correct hypocalcemia and other disorders (eg, Vit. D deficiency) prior to initiating; monitor serum calcium during therapy. Supplement diet ...