In the cerebral cortex, extrinsic and intrinsic excitatory glutamatergic pathways terminate on principal glutamatergic neurons and local inhibitory GABAergic interneurons. Activation of these pathways ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 34 (August 24, 2021), pp. 1-9 (9 pages) Dendrites play an essential role in the integration of highly ...

The result is a dizzyingly complicated network that is in a constant state of flux, rewiring itself on the fly in response to its environment and the life experience of its owner. The brain’s ability ...

The brain’s rules seem simple: Fire together, wire together. When groups of neurons activate, they become interconnected. This networking is how we learn, reason, form memories, and adapt to our world ...

Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells ...

Shedding light on how the brain fine-tunes its wiring during learning, a new study finds that different dendritic segments of a single neuron follow distinct rules. The findings challenge the idea ...

An interactive toolbox for standardizing, validating, simulating, reducing, and exploring detailed biophysical models that can be used to reveal how morpho-electric properties map to dendritic and ...

Learning is something everyone does daily—mastering new skills at work, remembering song lyrics, or following directions to new places. But behind these everyday tasks lies a complex biological ...

Faced with images that break the expected pattern, like a do not enter sign where a stop sign is expected, how does the brain react and learn compared to being shown images which match what was ...

Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal ...

Breakthroughs, discoveries, and DIY tips sent every weekday. Terms of Service and Privacy Policy. One of the brain’s most important properties is its flexibility ...